Lower plasma Coenzyme Q10 in depression
Michael Maes 1, Ivanka Mihaylova 1, Marta Kubera 2, Marc Uytterhoeven 3, Nicolas Vrydags 3, Eugene Bosmans 3 1 Maes Clinics, Belgium; 2 Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland; 3 AML Laboratory, Antwerp, Belgium;
DISCUSSION: This is a first study which shows that major depression is accompanied by a CoQ10 deficiency and that lower plasma CoQ10 is significantly related to treatment resistance and the presence of CFS in depression. †
Effects of Inhibiting CoQ10 Biosynthesis with 4-nitrobenzoate in Human Fibroblasts
Catarina M. Quinzii1, Saba Tadesse1, Ali Naini1,2, Michio Hirano, 1 Department of Neurology, Columbia University Medical Center, New York, New York, United States of America, 2 Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York, United States of America
DISCUSSION: Depending on the severity of CoQ10 deficiency, biochemical targets for therapy may vary and may be relevant to other mitochondrial respiratory chain disorders. Moreover, the results may be germane to the pathogenesis and therapies of other neurodegenerative diseases with mitochondrial dysfunction..†
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† These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.