ISO Brain

Premium
NootropicBrain Supplement

Nootropics are substances that can enhance memory, brain health, focus, mood and other cognitive processes — while safely supporting and protecting different areas of the brain. †

“Man is not going to wait passively for millions of years before evolution offers him a better brain.” — Corneliu E. Giurgea, 1972

Caffeine-free · Made in the USA · 15 premium ingredients

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Real people. Real results.

Made in the USA
Caffeine free
Gluten free
GMP standards
ISO Brain 100% Transparency Promise

Transparent like our bottles.

We show you an itemised breakdown of the exact amount of every ingredient. You will not open a clear ISO Brain bottle to find it half-full like a bag of chips — you know exactly how much of each ingredient you're taking.

No proprietary blends. No fillers hiding the dose. Designed for intelligent people who make intelligent decisions.

Supplement Facts

Serving size: 2 capsules · 30 servings per container. Every one of the 15 premium ingredients is listed on the label with its exact amount.

Jitter-free. No speedy feeling. Caffeine free.
100% Transparency Promise

15 Premium Ingredients

Every ingredient, its form and its exact amount — chosen from published nootropic research.

Cognizin® (Citicoline)

125 mg

A patented form of citicoline for attention, focus and recall. Clinical studies show it helps improve attention, motor speed and brain activity. †

Acetyl L-Carnitine (ALCAR)

333 mg

An amino acid that helps produce energy in the mitochondria and crosses the blood-brain barrier. Supports acetylcholine — memory, learning and analysis. †

Lion's Mane (Hericium Erinaceus)

216 mg

An edible, medicinal mushroom that can induce Nerve Growth Factor synthesis. A double-blind, placebo-controlled trial showed increased cognitive-function scores. †

N-Acetyl L-Tyrosine (NALT)

112 mg

A building-block amino acid used to support mood, attention and cognition, and studied for anxiety, ADHD and chronic fatigue. †

Rhodiola Rosea Extract (5% Rosavins)

106 mg

A perennial adaptogen shown in clinical trials to provide anti-fatiguing benefits for brain function. †

N-Acetyl Cysteine (NAC)

100 mg

Derived from the amino acid L-cysteine — a strong antioxidant, and one of the few supplements studied to help with hangover symptoms. †

Bacopa Monnieri Extract (50% Bacosaponins)

94 mg

From the Brahmi plant of India, used in traditional medicine for centuries. A 2013 study showed potential to improve cognitive performance and speed of attention. †

Turmeric Extract (95% Curcuminoids)

87 mg

Curcumin, the phenolic component of yellow curry spice, studied for neuroprotective and cognitive-enhancing properties. †

Phosphatidylserine (from Soy)

74 mg

A phospholipid and component of the cell membrane. Soy-PS taken for 6 months improved memory function — especially delayed recall — in older adults with memory complaints. †

DMAE (Dimethylaminoethanol Bitartrate)

58 mg

A precursor to acetylcholine, one of the main memory-forming neurotransmitters; higher acetylcholine has been linked with better memory performance. †

Coenzyme Q10 (CoQ10)

50 mg

A compound present in the mitochondria of every cell, studied in the context of mood, energy and cognitive fatigue. †

Vitamin D3 (Cholecalciferol)

400 IU

An immune-system modulator the body makes from sunlight, with a crucial role in synaptic transmission and plasticity. Deficiency is common in winter. †

Vitamin B12 (Methylcobalamin)

12 mcg

The more bio-available form of B12, which plays a key role in the normal functioning of the brain and nervous system. †

Vitamin B6 (P5P)

Pyridoxal-5-P

The active form of B6 — a required coenzyme for GABA, dopamine, norepinephrine and serotonin. Studied for mood, memory and mental performance. †

Vitamin B3 (Niacin)

20 mg

A key co-enzyme in the production of cellular energy; research suggests it may help preserve and enhance neurocognitive function. †

Clinical Research

Built on published science.

Every ingredient in ISO Brain is drawn from published, peer-reviewed research. Below is the study evidence behind each one — 56 papers in total. What the studies used is what goes in the capsule.

Cognizin® (Citicoline)3 studies
Acetyl L-Carnitine10 studies
Lion's Mane2 studies
  • Neurotrophic properties of the Lion's mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia”The extract also enhanced the neurite outgrowth stimulation activity of NGF when applied in combination. The aqueous preparation of H. erinaceus had neurotrophic but not neuroprotective activities. Int J Med Mushrooms. 2013;15(6):539-54. Lai PL1, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Evid Based Complement Alternat Med. 2017;2017:3864340. doi: 10.1155/2017/3864340. Epub 2017 Jan 1. Brandalise F1, Cesaroni V2, Gregori A3, Repetti M2, Romano C2, Orrù G4, Botta L2, Girometta C5, Guglielminetti ML6, Savino E6, Rossi P7. Results: Intriguingly other neurobiological effects have recently been reported like the effect on neurite outgrowth and differentiation in PC12 cells. Until now no investigations have been conducted to assess the impact of this dietary supplementation on brain function in healthy subjects. Therefore, we have faced the problem by considering the effect on cognitive skills and on hippocampal neurotransmission in wild-type mice. In wild-type mice the oral supplementation with H. erinaceus induces, in behaviour test, a significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory synaptic current in mossy fiber-CA3 synapse. In conclusion, we have produced a series of findings in support of the concept that H. erinaceus induces a boost effect onto neuronal functions also in non-pathological conditions. · DOI →
  • Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial.The results obtained in this study suggest that Yamabushitake is effective in improving mild cognitive impairment. Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634. Mori K1, Inatomi S, Ouchi K, Azumi Y, Tuchida T. · DOI →
Rhodiola Rosea4 studies
Turmeric4 studies
Phosphatidylserine5 studies
DMAE1 study
N-Acetyl L-Tyrosine2 studies
N-Acetyl Cysteine5 studies
Bacopa Monnieri5 studies
Vitamin D33 studies
Vitamin B123 studies
Vitamin B65 studies
Vitamin B34 studies
Frequently Asked

Questions

What is a proprietary blend — and why doesn't ISO Brain use one?

A proprietary blend lists ingredients but hides the individual amounts, showing only a combined weight — so you never know how much of each active ingredient you're getting, and the bottle can be padded with cheap fillers like rice flour. ISO Brain does the opposite: itemised amounts for all 15 premium ingredients on every label. †

How much caffeine is in ISO Brain?

None. ISO Brain is 100% caffeine free — jitter-free focus with no speedy feeling and no crash. We don't recommend a proprietary blend with any caffeine; do your due diligence on nootropics that contain it. †

What is the "90-Day Money-Back Guarantee"?

In plain English: if you don't like it for any reason, give us a call within 90 days of purchase and we'll refund the full price of the supplement. Does not include shipping; valid on your first bottle. See our Terms & Conditions for details.

What is the ISO Brain 100% Transparency Promise?

ISO Brain was designed for intelligent people who make intelligent decisions. We believe in honesty and transparency — so we show you an itemised breakdown of the exact amount of every ingredient. You'll never open a clear ISO Brain bottle to find it half-full. †

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Cognizin® is a registered trademark of Kyowa Hakko Bio Co., Ltd. This page is informational; consult a healthcare professional before starting any supplement.