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Vitamin B6 Nootropic and Brain Supplement Benefits


Vitamin B6, also known as Pyridoxal 5 Phosphate (P5P), is a vital nutrient that plays a significant role in supporting cognitive health. In this article, we will delve into the nootropic benefits of Vitamin B6, how it contributes to Iso Brain’s efficacy, and the importance of incorporating this essential vitamin into your daily routine.

The Role of Vitamin B6 in Brain Health

Vitamin B6 is crucial for various cognitive functions, such as:

  1. Neurotransmitter Synthesis

    P5P is a coenzyme that helps facilitate the synthesis of neurotransmitters like dopamine, serotonin, and GABA. These neurotransmitters play a critical role in regulating mood, memory, focus, and overall cognitive function. A study published in the American Journal of Clinical Nutrition emphasizes the importance of Vitamin B6 in neurotransmitter synthesis.

  2. Homocysteine Regulation

    High levels of homocysteine, an amino acid, have been linked to cognitive decline and neurodegenerative diseases. Vitamin B6 helps regulate homocysteine levels by converting it into cysteine or methionine. A study published in the Journal of Neurology, Neurosurgery & Psychiatry highlights the association between Vitamin B6 and homocysteine regulation.

  3. Myelin Sheath Maintenance

    Vitamin B6 is vital for maintaining the myelin sheath, which covers and protects nerve fibers, ensuring efficient transmission of nerve impulses. A healthy myelin sheath is essential for optimal cognitive function. A review in the journal Nutrients outlines the role of Vitamin B6 in myelin sheath maintenance.

Synergy with Other Iso Brain Ingredients

Vitamin B6 works synergistically with other Iso Brain ingredients to support cognitive health. Here are a few examples:

  • Vitamin B12 (MethylCobalamin): Together with Vitamin B6, Vitamin B12 supports homocysteine regulation and neurotransmitter synthesis, promoting overall brain health.

  • Rhodiola Rosea Extract (5% Rosavins): Rhodiola Rosea enhances cognitive function by reducing fatigue and stress. In combination with Vitamin B6, it helps improve mental performance during challenging situations.

  • Phosphatidylserine (From Sunflower): Phosphatidylserine helps maintain cell membrane integrity and fluidity, facilitating efficient communication between brain cells. When combined with Vitamin B6, it supports optimal cognitive function.

Clinical Research on Vitamin B6 as a Nootropic

Numerous clinical research studies support the nootropic benefits of Vitamin B6:

  1. Cognitive Function and Memory

    A study published in the journal Appetite found that Vitamin B6 supplementation improved memory and cognitive function in healthy adults.

  2. Mood Enhancement

    A meta-analysis in the journal Psychosomatic Medicine demonstrated that Vitamin B6 supplementation could alleviate symptoms of depression by supporting the synthesis of mood-regulating neurotransmitters.


For additional clinical research on the ingredients in Iso Brain, visit our Clinical Research page.


Iso Brain: Safe and Effective Cognitive Support

Iso Brain is a carefully formulated nootropic supplement designed to support cognitive function, memory, and overall brain health. It contains Vitamin B6 (P5P) and other high-quality, well-researched ingredients, such as Vitamin D3 (Cholecalciferol), Vitamin B3 (Niacin), and Acetyl L-Carnitine (ALCAR). Iso Brain is safe to use as directed, providing essential nutrients for optimal cognitive performance.

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Nootropics Are Substances That Can Enhance Memory, Brain Health, Focus, Mood and Other Cognitive Processes, While Safely Supporting and Protecting Different Areas of the Brain. †

Impressive Statistics on Vitamin B6 as a Nootropic

Vitamin B6 is known to play a crucial role in supporting cognitive health and functioning. Numerous studies have investigated the benefits of Vitamin B6 as a nootropic, revealing some impressive results. Let’s dive into the statistics and research findings on Vitamin B6:

  1. Memory Enhancement: A 2012 study discovered that higher Vitamin B6 levels were associated with better memory performance in older adults. This suggests that maintaining adequate Vitamin B6 levels may help preserve memory function as we age.

  2. Mood Regulation: Research has shown that Vitamin B6 plays a role in the synthesis of neurotransmitters like serotonin and dopamine, which are essential for mood regulation. A 2019 systematic review concluded that Vitamin B6 supplementation may improve depressive symptoms in adults.

  3. Cognitive Decline Prevention: A 2014 review found that a combination of Vitamin B6, B12, and folic acid may help slow cognitive decline and reduce the risk of Alzheimer’s disease in older adults.

  4. Homocysteine Regulation: Elevated homocysteine levels are associated with an increased risk of cognitive decline and dementia. Vitamin B6, along with other B vitamins, helps regulate homocysteine levels. A 2017 study found that B-vitamin supplementation, including Vitamin B6, may improve cognitive performance in individuals with elevated homocysteine levels.

  5. Brain Function Support: A 2015 review showed that Vitamin B6 is involved in over 100 enzyme reactions, many of which are essential for proper brain function. This demonstrates the importance of maintaining optimal Vitamin B6 levels for overall cognitive health.

The research and statistics on Vitamin B6 as a nootropic are compelling, highlighting the significant impact this nutrient can have on cognitive health and performance. Iso Brain contains Vitamin B6, along with other synergistic ingredients like Cognizin® (Citicoline) and N-Acetyl L-Tyrosine (NALT), to provide comprehensive support for optimal brain function.

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Natural Sources of Vitamin B6 (P5P)

Vitamin B6, also known as pyridoxine, is an essential water-soluble vitamin that plays a vital role in numerous bodily functions, including cognitive health. It occurs naturally in various food sources and can also be taken in the form of supplements, like Iso Brain. Let’s explore some of the primary natural sources of Vitamin B6:

  1. Poultry: Chicken and turkey are rich in Vitamin B6, providing a substantial amount of this essential nutrient per serving.
  2. Fish: Fish, particularly salmon and tuna, contain significant levels of Vitamin B6, making them a great addition to a brain-healthy diet.
  3. Whole Grains: Whole grains, such as brown rice, oatmeal, and whole wheat bread, are excellent sources of Vitamin B6, contributing to a balanced and nutrient-dense diet.
  4. Legumes: Beans, lentils, and chickpeas are not only high in protein and fiber but also contain a good amount of Vitamin B6.
  5. Nuts and Seeds: Sunflower seeds, pistachios, and hazelnuts are rich in Vitamin B6, making them a convenient and nutritious snack option.
  6. Fruits and Vegetables: Some fruits and vegetables, such as bananas, avocados, and spinach, provide moderate amounts of Vitamin B6, further supporting a well-rounded diet.
  7. Fortified Foods: Certain foods, like breakfast cereals, are fortified with Vitamin B6 to help meet daily nutrient requirements.

By incorporating these natural sources of Vitamin B6 into your diet, you can support your body’s overall health and cognitive function. However, for a more concentrated and targeted nootropic effect, consider taking a supplement like Iso Brain, which combines Vitamin B6 with other powerful ingredients, such as Vitamin B3 (Niacin) and Lion’s Mane (Hericium Erinaceus). Together, these nutrients work synergistically to provide optimal cognitive support and enhance brain function.

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Discover the Synergy of Iso Brain’s Other Ingredients

While Vitamin B6 is a powerful nootropic on its own, Iso Brain combines it with other potent ingredients to create a comprehensive formula for cognitive enhancement. Let’s explore some of the other key ingredients in Iso Brain and their unique benefits:

  1. Vitamin D3 (Cholecalciferol): Known as the “sunshine vitamin,” Vitamin D3 is essential for overall health and has been linked to improved mood, cognitive function, and reduced risk of neurodegenerative diseases.

  2. Vitamin B3 (Niacin): This B-vitamin supports brain health by aiding in the production of essential neurotransmitters, improving blood flow to the brain, and providing antioxidant protection.

  3. Vitamin B12 (MethylCobalamin): Vitamin B12 is crucial for maintaining healthy nerve cells and supporting brain function, including memory and learning.

  4. Acetyl L-Carnitine (ALCAR): ALCAR is a powerful antioxidant that helps improve energy production in brain cells, support memory function, and protect against cognitive decline.

  5. Lion’s Mane (Hericium Erinaceus): A unique mushroom with neuroprotective properties, Lion’s Mane promotes nerve growth factor production and supports overall cognitive function.

  6. Cognizin® (Citicoline): Citicoline is a potent nootropic that supports memory, focus, and overall cognitive function by increasing brain energy production and neurotransmitter levels.

  7. N-Acetyl L-Tyrosine (NALT): A precursor to neurotransmitters like dopamine and norepinephrine, NALT helps improve focus, mood, and stress resilience.

  8. Rhodiola Rosea Extract (5% Rosavins): An adaptogenic herb known for its stress-fighting and brain-boosting properties, Rhodiola Rosea enhances mental performance and combats mental fatigue.

  9. N-Acetyl Cysteine (NAC): NAC is an antioxidant that supports brain health by promoting detoxification and defending against oxidative stress.

  10. Bacopa Monniera Extract (50% Bacosaponins): Bacopa is a traditional Ayurvedic herb that has been shown to improve memory, learning, and overall cognitive function.

  11. Tumeric Extract (95% Curcuminoids): Turmeric is a powerful anti-inflammatory and antioxidant that supports brain health by fighting inflammation and oxidative stress.

  12. Phosphatidylserine (From Sunflower): An essential phospholipid found in brain cell membranes, phosphatidylserine supports memory, learning, and overall cognitive function.

  13. Dimethylaminoethanol (DMAE Bitartrate):DMAE is a precursor to the neurotransmitter acetylcholine, which is involved in learning, memory, and cognitive function. By increasing acetylcholine levels, DMAE can help improve focus, mental clarity, and overall cognitive performance.

  1. Coenzyme Q10 (CoQ10): CoQ10 is a powerful antioxidant that plays a crucial role in energy production within brain cells. It helps protect the brain from oxidative stress and supports overall cognitive function.

These ingredients work synergistically to provide a comprehensive approach to cognitive enhancement. With Iso Brain, you can expect improvements in memory, focus, clarity, and overall brain health. By combining the power of Vitamin B6 with these other potent nootropic ingredients, Iso Brain offers an all-in-one solution for those seeking to optimize their cognitive performance.

Remember, for more information on the clinical research supporting the effectiveness of these ingredients, be sure to visit the Iso Brain Clinical Research page.

In conclusion, Vitamin B6 (P5P) is a powerful nootropic with numerous benefits for cognitive function, mood, and overall brain health. When combined with the other potent ingredients in Iso Brain, you get a comprehensive formula designed to enhance your cognitive abilities and support your brain’s long-term health. Don’t wait to unlock your full cognitive potential – order Iso Brain today and experience the difference for yourself!


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"ISO brain 100% transparency promise"

We are transparent like our bottles, showing you an itemized breakdown of the exact amounts of our ingredients. You will not open a clear ISO BRAIN bottle to find it half full like a bag of chips and you will know exactly how much you are taking of each ingredient.

Supplement Facts

Serving Size 2 Capsules
Servings Per Container 30

† Percent Daily Value not established

Other Ingredients: Gelatin Capsule (Sodium Lauryl sulfate, Glycerin, Brilliant Blue FCF, FD & C Red No. 40, Titanium Dyoxide), Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose, Maltrodextrin.

Coginizin® is a registered trademark of KYOWA HAKKO BIO CO, LTD.

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The Power of Vitamin B6 and Iso Brain

In conclusion, Vitamin B6 (P5P) is an essential nutrient for cognitive health and plays a crucial role in the nootropic potential of Iso Brain. By supporting neurotransmitter synthesis, homocysteine regulation, and myelin sheath maintenance, Vitamin B6 contributes to enhanced memory, focus, and overall cognitive function. Combined with other potent ingredients in Iso Brain, Vitamin B6 works synergistically to help you achieve optimal cognitive performance.

Ready to experience the benefits of Vitamin B6 and other powerful nootropics in Iso Brain? Click here to shop now and give your brain the support it deserves.


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15 Premium Ingredients

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Vitamin B6 (P5P)

(Pyridoxal 5 Phosphate)5

Pyridoxal-5-Phosphate, or P5P as it is commonly known, is a more expensive and active form of vitamin B6. P5P is a required coenzyme for the biosynthesis of several neurotransmitters, including GABA, dopamine, norepinephrine, and serotonin. Some studies show P5P increasing mood, memory, performance and mental effort.†

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(ALCAR) 333mg

An amino acid that is naturally produced in the body which helps produce energy and can help increase energy production in the mitochondria. This acetylated version of carnitine is able to cross the blood-brain barrier. Its primary effect is on the production of acetylcholine which is one of the main neurotransmitters involved in memory, learning, computation, analysis and many other cognitive processes.†

LionsMane2 compact


(Hericium Erinaceus) 216mg

Hericium Erinaceus (also called Lion’s Mane) is an edible and medicinal mushroom. Lion’s Mane can induce Nerve Growth Factor synthesis in nerve cells which is essential for the maintenance of the basal forebrain cholinergic system. A double-blind placebo-controlled clinical trial study showed increased cognitive function scores for people who took Lion’s Mane vs a placebo group. †

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Bacopa Monniera Extract

(50% Bacosaponins)94mg

Created from the Brahmi plant which is native to the wetlands of India and has been a consistent part of traditional medicine for centuries. A 2013 study demonstrated that Bacopa Monniera extract has a potential to improve cognitive performance, particularly speed of attention by reducing choice reaction time.†

tumeric compact


(95% Curcuminoids) 87mg

Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation. Recent studies show that curcumin also possesses neuroprotective and cognitive-enhancing properties.†

Phosphatidylserine 01 medium


(From Soy) 74mg

Phosphatidylserine is a phospholipid and is a component of the cell membrane. It plays a key role in cell cycle signaling, specifically in relationship to apoptosis. In a recent Japenese study, with oral administration of Soy-PS for 6 months improved memory function, especially delayed recall, in the elderly with memory complaints. †

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An amino acid considered a “building block” of protein. in some cases L-Tyrosine is also used to treat depression, anxiety, ADHD, cognitive disorders and treat chronic fatigue syndrome.†

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(5% Rosavins)106mg

Rhodiola rosea is a perennial flowering plant in the family Crassulaceae. In some clinical trials Rhodiola Rosea has been found to show anti fatiguing benefits for brain function.†

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N-acetyl cysteine (sometimes refered to as NAC) comes from the amino acid L-cysteine, that has been known as a strong antioxidant and one of the few supplements to help combat hangover symptoms from Alcohol.†

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(DMAE Bitartrate) 58mg

DMAE is a precursor to acetylcholine, which is one of the main memory-forming neurotransmitters in your brain. Higher acetylcholine levels have been linked with better performance on some memory tests.† As a nootropic, it is closely related to choline but due to a slightly different chemical structure it crosses the blood-brain barrier differently.†

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(Cholecalciferol) 400 IU

Vitamin D acts an immune system modulator and can be produced by the body using sunlight. present findings signify the crucial role of Vitamin D on the basic synaptic transmission and synaptic plasticity.† Due to weather changes, deficiency is common during the winter months. A recent study suggests that Vitamin D(3) supplementation during the winter may reduce the incidence of flu by 40%†

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(CoQ10) 50mg

COQ10: Co-Enzyme Q10 is a compound present in mitochondria of every cell in the body. the results show that lower COQ10 plays a role in the pathophysiology of depression and in particular in TRD and CFS accompanying depression.† COQ10 supplementation also has been known to promote slower brain deterioration, as seen in a study published in the 2002 “archives of neurology.” †

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Cognizin®​ delivers a patented form of citicoline. Citicoline is a brain health ingredient that provides support for attention, focus and recall. Clinical studies have shown Cognizin to help improve attention, focus, motor speed and increase brain activity. †
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MethylCobalamin is more Bio-Available and expensive form of B12. The vitamin plays a key role in the normal functioning of the brain and nervous system.†

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(Niacin) 20mg

Also known as Niacin. this vitamin is known as a key Co-Enzyme in the production of cellular energy. Data from research suggests Vitamin B3 may be beneficial in preserving and enhancing neuroconitive function.†

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